The modern diabetes drugs and medication have the potential to reverse Type 2 Diabetes. While Metformin diabetes medication reduces insulin resistance, Sulfonylureas help in improving insulin secretion, Thiazolidinediones/Glitazomes also reduce insulin resistance. Drugs which are broadly classified as ‘Incretin-based therapies’ too have shown the ability to reverse pancreatic cell failure and cause pancreatic cell regeneration in animal models. These drugs work by activating the Incretin hormonal system in the human gut, stimulating insulin production and inhibiting glucagon (anti-insulin hormone) production from the pancreas in response to food in the stomach. This improves glycaemic control without the risk of blood sugar levels dropping and causing hypoglycaemia. Additionally, they may cause weight reduction. These drugs are of 2 types-the GLP1 analogues extracted from the saliva of the Gila monster and the DPP IV inhibitors.
Newer insulins known popularly as ‘Designer Insulins’ have been developed which provide a much more physiological insulin delivery for those requiring insulin. In addition, they prevent weight gain and have a much lower risk of causing hypoglycaemia-two of the most unwanted side effects of insulin.
Insulin pumps produce streamlined and continuous insulin delivery into the individual resulting in excellent blood sugar control, as they can be adjusted and refilled every 4-5 days. Even though diabetes continues to persist in epidemic proportions in the US, newer developments in diabetes management have given more than a glimmer of hope to many diabetics. Today, with regular scientifically-proven treatment, they can definitely hope for a long and healthy life.
